With the improvement of laboratory monitoring methods, the sensitivity of TSH monitoring is getting higher and higher, and high-sensitivity thyroid-stimulating hormone is a more sensitive monitoring value of thyroid-stimulating hormone, which reflects TSH value more accurately and can predict the occurrence of disease earlier.

Some scholars have keenly discovered the relationship between high-sensitivity TSH levels and thyroid tumors. Preoperative high-sensitivity TSH levels in patients with thyroid cancer were significantly higher than those in patients with benign thyroid nodules. In addition, the high-sensitivity TSH level is also correlated with lymph node metastasis and tumor recurrence in thyroid cancer. In patients with thyroid cancer, the higher the preoperative high-sensitivity TSH level, the more prone to lymph node metastasis, and the higher the risk of postoperative recurrence. Increased high-sensitivity TSH is not only a high-risk factor for thyroid cancer, but also an important indicator for predicting the prognosis of thyroid cancer.

There are three key requirements for the performance of thyroid function detection reagents: sensitivity, specificity, and precision, and the key factor determining the performance of the reagents lies in the development and verification of its core biological raw materials. The raw material product of thyroid function testing is a key research and development project. After rigorous program design and a large number of experimental verifications, DIAGREAT developed high-quality antigens and antibodies, conjugates, high-sensitivity pairing raw materials, POCT bulk sheet, etc. for thyroid function testing which have been widely used.

High-sensitivity TSH key raw material products

High-sensitivity TSH paired antibody

● It is almost the most sensitive TSH pairing raw material on the market.

Fully meets the requirements of the 'third generation' functional sensitivity specification [0.01–0.02 μIU/mL with inter-assay %CV ≤ 20%]

01

Ultra high sensitivity within 5 minutes to easily meet the needs of the third generation of high-sensitivity TSH

‖ Reaction program: 30S+50M(TSH Cap Ab-Mag) +50R1(TSH Det02 Ab-ALP) reaction→substrate

Substrate

Reaction time

02

Good clinical relevance

‖ Consistently excellent clinical relevance compared to well-known imported brands, full range R²=0.99

Ultra-high specificity

‖ The cross-reactivity rate is always <0.005% regardless of TSH concentration

TSH concentration     Concentration of cross-substance added    Cross reaction rate

Self-developed TSH protein - eukaryotic expression without Tag

Ultra high stability

‖ Compared with well-known imported brands, TSH protein still maintains good stability under long-term acceleration, with almost no downward trend

20mM PB 8.0，2％BSA，0.9％NaCl，2mM EDTA，0.1％PC-300

Liquid stability (TSH protein configuration is 0.7uIU/mL)

20 mM PB 8.0, 2% BSA, 0.9% NaCl, 2 mM EDTA, 0.1% PC-300

Assessment days   DIA-UP TSH protein           Imported natural TSH protein

Other raw materials for thyroid function

Thyroid function