Diagreat Biotech Launches CK-MB Mass Determination Product
发布日期：
2024-03-20
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Creatine kinase isoenzyme MB (CK-MB)

Diagreat Biotech Launches CK-MB Mass Determination Product

Creatine kinase (CK) is one of the important diagnostic enzyme detection indicators in human blood and is widely distributed in skeletal muscle, myocardium, gastrointestinal, brain tissue, etc. CK has a dimeric structure, including two subunits, M and B, so there are three isoenzymes: CK-MM, CK-MB, and CK-BB.

Creatine kinase isoenzyme MB (CK-MB) is a sensitive and specific marker of myocardial tissue damage. CK-MB rises 4-6 hours after onset and returns to normal within 3-4 days. It has highly specificity for judging myocardial infarction. Its concentration can roughly determine the extent of infarction; it can determine the time of myocardial damage and diagnose early reinfarction.


CK-MB

clinical significance



01

Diagnosis of myocardial infarction


02

Detection of myocardial reinfarction


03

Non-invasive assessment of reperfusion


04

Prognostic assessment of ACS





Advantages of CK-MB mass method


Diagreat Biotech Launches CK-MB Mass Determination ProductDiagreat Biotech Launches CK-MB Mass Determination Product

Diagreat Biotech Launches CK-MB Mass Determination Product

When placed at room temperature, the activity of CK-MB will gradually decrease over time, but the mass of CK-MB has always been at a relatively stable level. For the specimens that need to be reviewed, the mass of CK-MB has significant advantages.



CK-MB Mass Method Guide



Guideline




















01

 "Guidelines for Rapid Diagnosis and Treatment of Acute Coronary Syndrome in Emergency" (2019)

Main content: If cTnI/T cannot be detected, CK-MB mass testing should be used instead. CK-MB mass testing can evaluate the effect of thrombolytic therapy and the presence of reinfarction or enlargement of infarction lesions in the early stages of AMI when cTn (hs-cTn) levels increase.

02

"Introduction to the Guidelines for the Application of Cardiac Markers by the American Academy of Clinical Biochemistry" (2007)

In cases where cTn determination is not possible, CK-MB mass determination can be used as an alternative method.

03

"Recommendations for the Clinical Detection of Cardiac Markers in Coronary Artery Disease and Heart Failure" (2006)

CK-MB mass determination has better analytical and diagnostic utility and is significantly better than activity determination.

04

 "Fourth Universal Definition of Myocardial Infarction" (2018) The fourth edition of the global unified definition of myocardial infarction

In the absence of cTn detection, the best alternative is the CK-MB mass assay.

05

 "Detection and Clinical Application of Cardiac Markers in Coronary Artery Disease and Heart Failure" (Health Industry Standard of the People's Republic of China WS/T 462-2015)

When there is no condition to use cTn, the detection method of CK-MB (CK-MB mass method is recommended) or total CK can be used.




Ording information




Diagreat Biotech Launches CK-MB Mass Determination Product



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