Human Epididymis Protein 4(HE4) CLIA kit (Chemiluminescence Immunoassay) is an in vitro diagnostic quantitative test kit. Human epididymis protein 4 (HE4) was first identified in the epithelium of thedistal epididymis. The assay is used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer.