PRODUCT NAME:

Product Name: Insulin CLIA Kit (Chemiluminescence Immunoassay) Abbreviation: INS 

INTENDED USE:

Insulin CLIA Kit (Chemiluminescence Immunoassay) is an in vitro diagnostic test for the quantitative detection of insulin (INS) in human serum and plasma. This product is intended to be used by laboratory professional workers only. This kit is used for auxiliary diagnosis. Results must be combined with clinical observations, patient history, other laboratory parameters, and epidemiological information. Insulin is a protein hormone synthesized, stored and secreted by the β cells of the pancreatic islets in the pancreas. Insulin is responsible for regulating the concentration of glucose in the blood. In β cells, insulin exists as a macromolecule (molecular weight - 12,000) called preproinsulin. Preproinsulin is a single-chain precursor containing 110 amino acids. Preproinsulin splits into a chain of 24 amino acids to form proinsulin (molecular weight - 9000), the precursor to insulin and C-peptide. Proinsulin is composed of two disulfide-linked amino acid chains and a linking C-peptide. Proinsulin is stored in the secretory granules of the β-cell Golgi apparatus (GA), and after proteolysis, insulin (molecular weight - 6000) and C-peptide (molecular weight - 3000) are formed. At the cell membrane, insulin and C-peptide are released into the portal circulation in equal molar amounts. Insulin is the only hormone in the body that lowers blood sugar, while promoting glycogen, fat, and protein synthesis. Insulin measurement is a reliable method for diagnosing diabetes and judging the type of diabetes, and it is also an important indicator to reflect the reserve and secretion function of insulin cells. Detection, including fasting and postprandial insulin secretion levels, can better understand the severity of diabetes, help determine prognosis, and formulate corresponding treatment plans. In addition, insulinoma, NIDDM, Autoimmune Insulin Syndrome (Autoimmune Insulin Receptor Antibody and Insulin Antibody Syndrome), Liver Disease, Acromegaly, Cushing's Syndrome, Myotonic Dystrophy, Hereditary Fructose and galactose intolerance, obesity, etc. may lead to increased insulin. IDDM, anterior pituitary insufficiency, pancreatitis, etc. may lead to decreased insulin.