PRODUCT NAME:
Product Name: C Peptide CLIA Kit (Chemiluminescence Immunoassay)
Abbreviation: CP
INTENDED USE:
C Peptide CLIA Kit (Chemiluminescence Immunoassay) is an in vitro diagnostic test for the
quantitative detection of C Peptide (CP) in human serum, plasma and urine specimen. This product
is intended to be used by laboratory professional workers only. This kit is used for auxiliary
diagnosis. Results must be combined with clinical observations, patient history, other laboratory
parameters, and epidemiological information for comprehensive analysis.
C peptide, also known as connecting peptide, is a polypeptide consisting of 31 amino acids. It forms
proinsulin together with the A and B chains of insulin, and is the connecting chain of the A and B
chains, and plays an important role in the folding of the proinsulin molecule and the correct pairing
of disulfide bonds. Both C peptide and insulin are polypeptide secreted by pancreatic β-cells and
co-exist in the same granule capsule and are eventually secreted in equal molecules. At first, C
peptide was considered to be inactive, and it was only used to combine with insulin to determine the
function of pancreatic islet β cells. At present, C peptide is believed to be a peptide hormone with
various biological activities and is an important pathophysiological basis for the deficiency of
pancreatic islet β cells secreted insulin. The elimination rate of C peptide in the body is slow, with a
half-life of 20 min. It is not metabolized by liver enzymes, but mainly eliminated by the kidneys.
Therefore, the concentration in peripheral blood is higher and more stable, so it can more accurately
reflect the function of pancreatic islet β cells. In addition, urinary C peptide detection is of great
significance. C peptide is mainly excreted from urine, and the 24-hour urinary C peptide excretion
rate is significantly correlated with the insulin secretion rate. Therefore, urinary C peptide level is a
very important indicator for evaluating endogenous insulin secretion. Blood C peptide can only
reflect the instantaneous level of C peptide in blood, while urinary C peptide can reflect the average
value of C peptide in blood over a period of time, and sample collection of urine is more convenient
than blood. Urine C peptide is not affected by proinsulin, because the latter is less excreted in urine,
and there is no overlap in C peptide concentration between type I and type II diabetes, so the
detection of urinary C peptide can better reflect the secretion of pancreatic islet β cells ability.