C Peptide CLIA Kit


Product Name: C Peptide CLIA Kit (Chemiluminescence Immunoassay) Abbreviation: CP 


C Peptide CLIA Kit (Chemiluminescence Immunoassay) is an in vitro diagnostic test for the quantitative detection of C Peptide (CP) in human serum, plasma and urine specimen. This product is intended to be used by laboratory professional workers only. This kit is used for auxiliary diagnosis. Results must be combined with clinical observations, patient history, other laboratory parameters, and epidemiological information for comprehensive analysis. C peptide, also known as connecting peptide, is a polypeptide consisting of 31 amino acids. It forms proinsulin together with the A and B chains of insulin, and is the connecting chain of the A and B chains, and plays an important role in the folding of the proinsulin molecule and the correct pairing of disulfide bonds. Both C peptide and insulin are polypeptide secreted by pancreatic β-cells and co-exist in the same granule capsule and are eventually secreted in equal molecules. At first, C peptide was considered to be inactive, and it was only used to combine with insulin to determine the function of pancreatic islet β cells. At present, C peptide is believed to be a peptide hormone with various biological activities and is an important pathophysiological basis for the deficiency of pancreatic islet β cells secreted insulin. The elimination rate of C peptide in the body is slow, with a half-life of 20 min. It is not metabolized by liver enzymes, but mainly eliminated by the kidneys. Therefore, the concentration in peripheral blood is higher and more stable, so it can more accurately reflect the function of pancreatic islet β cells. In addition, urinary C peptide detection is of great significance. C peptide is mainly excreted from urine, and the 24-hour urinary C peptide excretion rate is significantly correlated with the insulin secretion rate. Therefore, urinary C peptide level is a very important indicator for evaluating endogenous insulin secretion. Blood C peptide can only reflect the instantaneous level of C peptide in blood, while urinary C peptide can reflect the average value of C peptide in blood over a period of time, and sample collection of urine is more convenient than blood. Urine C peptide is not affected by proinsulin, because the latter is less excreted in urine, and there is no overlap in C peptide concentration between type I and type II diabetes, so the detection of urinary C peptide can better reflect the secretion of pancreatic islet β cells ability.