Recently, a piece of news has attracted widespread attention, drawing attention to the safe use of medication. According to Fujian Health News reported on October 18, 40-year-old Ms. Zhang (a pseudonym) in Fuzhou, Fujian, with a history of hypertension for more than a year, bit off the antihypertensive drug with her teeth and ate most of the tablet. Eventually, due to low blood pressure unconsciousness was sent to the local hospital for treatment. It turned out that Ms. Zhang was taking nifedipine controlled-release tablets, a drug 1 tablet equivalent to the dose of 3 ordinary nifedipine tablets. Once chewed, broken, and ground to take, large doses of antihypertensive drugs will be instantly released into the body resulting in a sudden and significant drop in blood pressure.

In addition, Hangzhou First People's Hospital reported that it had recently diagnosed a case of brain atrophy in a 23-year-old nurse named Xiao Tu. The patient, a 23-year-old nurse, had a history of epilepsy for more than six years, and had been taking “loose drugs” provided by a primary healthcare organization without controlling the dosage, which led to a serious overdose of phenytoin sodium in her body. Phenytoin sodium is an antiepileptic drug that has long been widely used in clinical practice, and its therapeutic window is quite narrow. When the blood concentration exceeds the therapeutic window, it is easy to produce toxic reactions. Currently, there is no antidote for phenytoin sodium poisoning, which means that Xiaotu's cerebellar atrophy is irreversible.

Similar such painful cases have been staged, so for the majority of the need for long-term use of drugs, especially the toxic effect of the most effective means of prevention of the population is to standardize the use of drugs, do not arbitrarily change the doctor's orders, on time and in accordance with the amount of medication, and with the monitoring of the blood drug concentration, to ensure that the efficacy of the same time to minimize the side effects.