IL-6 : Sensitively Captures Early Signs of Infectious Diseases

Infectious disease burden

Reducing the mortality burden from infection is an urgent global public health priority. Reducing the number of deaths from infection is a fundamental principle for achieving health equity, as low- and middle-income countries have a disproportionate burden of infectious diseases. Previous studies have estimated the number of deaths related to drug-resistant infections and sepsis and found that infections remain the leading cause of death globally [1]. A recent study estimated that more than 10 million people died from sepsis in 2017, suggesting that more than 20% of global deaths that year were infection-related [2].
Most infectious diseases can be completely cured in a relatively short period of time as long as they are diagnosed accurately and treated appropriately. Diagnosing infectious diseases by relying solely on symptoms, signs and imaging findings sometimes encounters difficulties. Some non-infectious diseases may also have clinical manifestations that resemble infections. In this case, the detection of infection-related biomarkers is very important for differential diagnosis. The reference is more meaningful. In addition to the diagnosis of infectious diseases, certain biomarkers are also very helpful in determining the prognosis of patients and determining the course of anti-infective treatment. They can even help to distinguish the pathogens causing infection to a certain extent [3].


The earliest inflammatory marker-interleukin-6

Interleukin-6 (IL-6) is an important member of the cytokine network and plays a central role in acute inflammatory responses. It can mediate the acute phase response of the liver and stimulate the production of C-reactive protein (CRP) and fibrinogen. IL-6 is the earliest marker to increase when inflammation occurs [3]. A variety of infectious diseases can lead to an increase in serum IL-6 levels, and IL-6 levels are closely related to patient prognosis. In addition, IL-6 is of great significance for the determination of sepsis and disease severity [4] and is a new indicator for tumor prognosis evaluation.
The detection of IL-6 concentration in the body >7 pg /mL indicates the possibility of inflammation or other infections. If it is >250 pg /mL, it is likely to be a very severe systemic inflammatory reaction (sepsis).

IL-6 : Sensitively Captures Early Signs of Infectious Diseases

Figure 1 Kinetic changes in various inflammatory markers in the body after endotoxin stimulation [5]


Diagreat Inflammation Marker Rapid Test Solution

Diagreat's Interleukin-6 Determination Kit (Fluorescence Immunochromatographic Assay) is one of the rapid test products of Diagreat's inflammatory marker series and is suitable for early diagnosis and prognosis assessment of infectious diseases. Only 50 μL of serum, plasma or whole blood sample can be used to achieve rapid, accurate and quantitative detection of IL-6 in patients, with results available in 20 minutes.
For inflammatory and infectious diseases, joint detection of PCT, IL-6, and CRP can not only improve the early diagnosis rate of infection, avoid missed diagnosis, but also reduce misdiagnosis.

————————————————————————————————Advantages of Diagreat Biotech POCT platform (Fluorescence Immunochromatographic Assay):

The instrument is portable, fast in detection and easy to operate.


Diagreat POCT inflammatory marker series

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IL-6 : Sensitively Captures Early Signs of Infectious Diseases


[1] GBD 2019 Antimicrobial Resistance Collaborators. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 [J]. Lancet, 2022, 400(10369): 2221-2248.

[2] Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study [J]. Lancet, 2020, 395: 200- 211.

[3] Infectious Diseases Professional Committee of the Chinese Medical Education Association.
Expert consensus on the interpretation of clinical significance of infection-related biomarkers [J]. Chinese Journal of Tuberculosis and Respiratory Medicine, 2017, 40(4): 243-257.

[4] Emergency Medicine Branch of China Association for International Exchange of Medical Care,
Emergency Medicine Branch of Chinese Medical Association,
Emergency Physician Branch of Chinese Medical Doctor Association,
etc. Consensus of Chinese Emergency Medicine Experts on Early Prevention and Intervention of Sepsis [J]. Chinese Journal of Emergency Medicine, 2020, 40(7): 577-588.

[5] Reinhart K, Meisner M, Brunkhorst FM. Markers for sepsis diagnosis: what is useful? [J]. Crit Care Clin, 2006, 22(3): 503-519.

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