A new weapon efficiently enabling VB12 detection reagent development - highly active intrinsic factor (IF)
发布日期:
2023-05-23
浏览次数:
0

Intrinsic factor is a glycoprotein secreted by gastric parietal cells. IF combines with vitamin B12 to form a complex, which has strong resistance to proteolytic enzymes, prevents vitamin B12 from being decomposed and destroyed, and promotes the absorption of vitamin B12 by the ileal epithelium.


 

The above process is the only way for the human body to absorb vitamin B12. Once the secretion of intrinsic factor is deficient or the body produces antibodies against intrinsic factor, it will greatly affect the absorption of vitamin B12, and then affect the production of red blood cells, resulting in pernicious anemia and higher stomach cancer risk.

 

According to the combination principle of IF and vitamin B12, IF is mainly used in the determination of serum vitamin B12.

 


Intrinsic factor (IF)

 

 

                                         

IF

Product name

Item No.

Type

Recommended use

Intrinsic factor


Recombinant protein

Development of VB12 related reagent

 

Intrinsic factor (IF) products

 

 

 

Appearance: colorless liquid

Buffer system: 20mM PB, 30mM KCL, pH7.4

Purity: ≥95% by SDS-PAGE

Concentration: see test tube label

Filtration: 0.22um

Scope of application: This product is suitable for the development of VB12 related reagents.

Storage conditions: For long-term storage, please freeze below -20°C and avoid repeated freezing and thawing.

 

 

 

01 Performance display

 

High purity, high activity, and small Inter-assay difference

 

 

A new weapon efficiently enabling VB12 detection reagent development - highly active intrinsic factor (IF)

 

Peak results

Name

Retention time (min)

Area (μV*s)

Hight (μV)

% area

Purity 100%

 

02 Free trial of new products for a limited time

 

Product name

Item No.

Trial pack quantity

Recommended use

Intrinsic factor


50

Development of VB12 related reagent

 


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