Ammonia(AMN) Determination Reagent is an in vitro diagnostic quantitative test kit. Ammonia, derived from the catabolism of amino acids and from the action of intestinal bacteria on dietary protein, is converted to urea in the liver hepatocytes and so rendered non toxic. Under normal circumstances the concentration of ammonia in the circulation remains low, typically less than 50 µmol/L (85 µg/dL). Studies have shown that excess ammonia can have a toxic effect on the central nervous system and clinical manifestations are typically neurological disturbances.